アスコルビン酸イソプロピリデン化合物のモルモットにおける抗壊血病効果について

概要

論文の詳細を見る
The antiscorbutic activity of 5,6-O-isopropylidene ascorbic acid (IAsA) and 5,6-O-isopropylidene ascorbic acid 2-sulfate (IAsS) in Hartley guinea pig fed a scorbutigenic diet has been investigated. Oral administration (0.1 mmol/animal) of IAsA completely prevented development of scurvy and continued to increase in body weight throughout the feeding experiment in guinea pig. An equimolar dose of IAsS did not prevent scurvy, and total vitamin C levels in tissues of IAsS-administrated animals were similar to those in C-free animals. The vitamin C Levels (μmol/ml or g) of IAsA, ascorbic acid (ASA), IAsS, and vitamin C deficient groups after the feeding test (IAsA, ASA group : 40 days, IAsS, C deficient group: 20 days) were 0.14, 0.11, 0.01, and 0.01 in blood, 4.90, 3.97, 0.07, and 0.05 in liver, 1.89, 1.47, 0.08, and 0.02 in kidney, respectively.
日本ビタミン学会の論文
1981-01-25