ビタミン関連酵素の多型とテーラーメイド栄養

概要

論文の詳細を見る
Present recommended dietary allowance (RDA) is based on average requirement obtained by statistics of large population, but the range of 2 times standard deviation may not cover the vitamin requirements owing to the genetic polymorphisms. For example, loaded vitamin C excretion by AA homozygotes of glutathione S-transferase 1-1 polymorphism (A342G(exon5)) was 66% larger than that by GA heterozygotes (p<0.007). The daily folate intake of 400 μg instead of the Japanese RDA (240 μg), was recommended for TT homozygotes of methylene tetrahydrofolate reductase gene polymorphism (C677T) in "Sakado Folate Project". This health interventions increased the average serum folate concentration of residents from 5 ng/mL to 8 ng/mL (p<0.0001), with a particularly large increase after genome announcement during a half year. Food fortification may be needed to provide enough vitamins for polymorphic individuals.
日本ビタミン学会の論文
2008-03-25