アスコルビン酸2-硫酸のモルモットに対する抗壊血病作用について

概要

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The antiscorbutic activity of ascorbic acid 2-sulfate (AsS) in young male of hartley guinea pigs fed the vitamin C-deficient diets has been investigated. The animal were diyided into five groups : 1) addition of 0.1mmol ascorbic acid (AsA)/animal/day, 2) addition of 0.1 mmol AsS/animal/day, 3) addition of 0.2mmol AsS/animal/day, 4) addition of 0.5mmol AsS/animal/day, and 5) control-no supplement, the feeding test were carried out for five weeks. In this experiment, AsS would be difficult to prevent the scurvy in the guinea pig. Change of vitamin C contents in tissues and blood of guinea pigs were followed for 16 days as the second experiment. The animals were divided into four groups, and supplemented with the following : 1) 0.1mmol AsA/animal/day, 2)0.5mmol AsS/animal/day, 3) 1.0mmol AsS/animal/day, and 4) control-no supplement. The vitamin Clevels of liver, kidney and blood in AsS-treated animals were similar to those of scorbutic animals. These investigation has shown that AsS is devoid of antiscorbutic activity in the guinea pig.
日本ビタミン学会の論文
1976-01-25