Saccharomyces cerevisiae菌浮遊液によるデスチオビオチンよりビオチンの生合成 : (IV)ビオチン生合成における硫黄源(3)S-Adenosylmethionineと5'-Methylthioadenosine

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The efficiency of S-adenosylmethionine and methylthioadenosine as sulfur source in the biosynthesis of biotin from desthiobiotin by washed cells of Saccharomyces cerevisiae, which were deficient in biotin and sulfur, was investigated. In the liquid medium containing desthiobiotin, Saccharomyces cerevisiae grew enough in response to S-adenosylmethionine and methionine, whereas it did not grow in the case of methylthioadenosine. S-Adenosylmethionine and methionine were incorporated into the cells by the addition of glucose better than without glucose. But 5'-methylthioadenosine was not incorporated, irrespective of the presence or absence of glucose. S-Adenosylmethionine and methionine had the almost same efficiency as sulfur source in the biosynthesis of biotin.
1964-02-25