Lysis of Rabbit γ-Globulin-Coupled Liposomes by the Complement System

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概要

• 論文の詳細を見る

• The lysis of rabbit γ-glibulin (RGG)-coupled liposomes by the complement system was measured with and without the addition of anti-RGG antibody. The complement activity obtained from lysis with the anti-RGG antibody was well correlated with that of the CH50 hemolytic complement test (r=0.92). The degree of lysis without anti-RGG antibody was strongly affected by the addition of factor I and the pretreatment of serum with zymosan. Althouth the addition of C4 to C4-deficient serum remarkably increased the lysis with anti-RGG antibody, it had little affect on that without anti-RGG antibody. From these results, the lysis without anti-RGG seemed to be caused by the alternative pathway, and thus RGG-coupled liposomes can be used for measuring the activities of both the total and alternative pathway of complement.

• 公益社団法人日本生物工学会の論文
• 1992-08-25

著者

• Fukuda Hideki

  Department Of Molecular Science And Material Engineering Graduate School Of Science And Technology K

• Fukuda H

  Kobe Univ. Kobe Jpn

• Fukuda Hideo

  Dept. Appl. Microbial Technology Kumamoto Institute Of Technology

• Fukuda Hideki

  Engineering Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.

• Katoh S

  Graduate School Of Science And Technology Kobe University

• KISHIMURA MASAAKI

  Engineering Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd.,

• KATOH SHIGEO

  Chemical Engineering Department, Kyoto University

• Taniguchi H

  Kobe Univ. Kobe Jpn

• Sada E

  Kyoto Univ. Kyoto

• Sada Eizo

  Chemical Engineering Department Kyoto University

• TANIGUCHI HIROSHI

  Second Department of Internal Medicine, Kobe University

• Kishimura Masaaki

  Engineering Research Laboratories Kaneka Corp.

• Taniguchi Hiroshi

  Second Department Of Internal Medicine Kobe University

• Katoh Shigeo

  Chemical Engineering Department Kyoto University

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