Reaction Mechanism of Prostaglandin E_2 Biosynthesis and Its Modeling
スポンサーリンク
概要
- 論文の詳細を見る
The reaction mechanisms of PGE_2 biosynthesis was investigated by a detailed examination of the cyclooxygenase and PGE_2-isomerase activities in acetone-pentane powder(microsomal fraction of ram seminal vesicular glands). Two main types of inactivating process were recognized in the reaction system. One type was due to irreversible inactivation caused by the oxidizing agent[O]_X released through the reduction of PGG_2 to PGH_2,while the other type was due to reversible inhibition which was supposed to be derived from the precursor arachidonic acid(AA). This inhibitor was found to block the activities of both cyclooxygenase and PGE_2-isomerase, and to compete with the substrates AA and PGH_2. Although no significant substrate inhibition was observed, arachidonic acid was slightly inhibitory toward PGE_2-isomerase.
- 公益社団法人日本生物工学会の論文
- 1991-01-25
著者
-
Katoh S
Graduate School Of Science And Technology Kobe University
-
Katoh Shigeo
Department Of Chemical Science And Engineering Graduate School Of Engineering Kobe University
-
KHEIROLOMOOM AZADEH
Department of Chemical Engineering, Kyoto University
-
Sada E
Kyoto Univ. Kyoto
-
Sada Eizo
Department Of Chemical Engineering Faculty Of Engineering Kyoto Univeristy
-
Kheirolomoom Azadeh
Department Of Chemical Engineering Kyoto University
-
KATOH SHIGEO
Department of Chemical Engineering, Kyoto University
関連論文
- BIOAFFINITY SEPARATION OF CONCANAVALIN A IN REVERSE MICELLAR SYSTEM COMPOSED OF AOT/BUTANOL OR NON-IONIC SURFACTANT
- Liposome Immune Lysis Assay of Antibodies by Liposomes Encapsulating Coenzyme β-NAD^+
- Production of Single-Chain Variable Fragment Antibody (scFv) in Fed-Batch and Continuous Culture of Pichia pastoris by Two Different Methanol Feeding Methods(BIOCHEMICAL ENGINEERING)
- Effects of Methanol Feeding Methods on Chimeric α-Amylase Expression in Continuous Culture of Pichia pastoris(BIOCHEMICAL ENGINEERING)
- Degradation of Cyanuric Acid in Soil by Pseudomonas sp. NRRL B-12227 Using Bioremediation with Self-Immobilization System(ENVIRONMENTAL BIOTECHNOLOGY)
- Neutralization of Acids by Microorganisms Co-Immobilized with Bacillus subtilis in a Shallow Layer of Model Soil
- Nutritional Enrichment of Larval Fish Feed with Thraustochytrid Producing Polyunsaturated Fatty Acids and Xanthophylls(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- A Simple Method for Measuring the Complement Activities of Both Classical and Alternative Pathways by Using Rabbit γ-Globulin-Coupled Liposomes
- Effects of Reconstitution of Membrane-Bound Lipoprotein Lipase and Dispersity of Substrate on Its Reaction Characteristics
- Substrate Specificity and Positional Preference of a Lipoprotein Lipase
- Angiotensin-I Converting Enzyme (ACE) Inhibitory Mechanism of Tripeptides Containing Aromatic Residues(BIOCHEMICAL ENGINEERING)
- ACE Inhibitory Activity and Characteristics of Tri-Peptides Obtained from Bonito Protein
- Secretion of α-Amylase from Saccharomyces cerevisiae and Pichia pastoris and Characterization of Its C-Terminus with an Anti-Peptide Antibody
- Characteristics of Neutralization of Acids by Newly Isolated Fungal Cells
- A Bioremediation Method Based on Self-Immobilization of Cells in Shallow Layer of Soil
- Overall Effectiveness Factor Incorporating Partition Coefficient for Gel-immobilized Enzyme Pellet
- Liposome Immunoblotting Assay Utilizing an Enhanced Chemiluminescent Reaction Improved by Surfactant
- Characteristics of a Perfusion-Type Support in Affinity Chromatography
- Elution Behavior of DNAs in Temperature-Gradient Affinity Chromatography for Single Nucleotide Polymorphism Detection
- Single nucleotide polymorphism detection method by temperature-gradient affinity chromatography using a single-stranded oligo-DNA coupled column
- High Efficiency Production of Astaxanthin in an Airlift Photobioreactor(BIOCHEMICAL ENGINEERING)
- Effect of Light Intensity and Frequency of Flashing Light from Blue Light Emitting Diodes on Astaxanthin Production by Haematococcus pluvialis(BIOCHEMICAL ENGINEERING)
- Effect of Flashing Light from Blue Light Emitting Diodes on Cell Growth and Astaxanthin Production of Haematococcus pluvialis(BIOCHEMICAL ENGINEERING)
- Effective Utilization of Transmitted Light for Astaxanthin Production by Haematococcus pluvialis(BIOCHEMICAL ENGINEERING)
- Fed-Batch Culture under Illumination with Blue Light Emitting Diodes (LEDs) for Astaxanthin Production by Haematococcus pluvialis(BIOCHEMICAL ENGINEERING)
- Effects of Nutrient Supply Methods and Illumination with Blue Light Emitting Diodes (LEDs) on Astaxanthin Production by Haematococcus pluvialis(BIOCHEMICAL ENGINEERING)
- Astaxanthin production by Haematococcus pluvialis under illumination with LEDs
- Utilization of antipeptide antibodies as affinity ligands in immunoaffinity purification
- ANALYSIS OF CHARACTERISTICS OF CRYOGENIC DISTILLATION COLUMN IN SEPARATION OF HYDROGEN ISOTOPES
- Improvement of Growth Stability of Photosynthetic Bacterium Phodobacter capsulatus(BIOCHEMICAL ENGINEERING)
- HETP Values of Large-Scale Columns for Liquid Chromatography
- A Simple Optimization Technique for Fed-batch Culture : Kinetic Studies on Fed-batch Cultures (VI)
- Epitope Screening by Use of a Random Peptide-Displayed Phage Library and Polyclonal Antibody-Coupled Liposomes
- A Rapid Method for Determination of the Association Constant of Monoclonal Anibodies
- Lysis of Rabbit γ-Globulin-Coupled Liposomes by the Complement System
- Recognition of Size and Charged States of Antigens by Anti-Peptide Antibodies
- Resistance to Proteolysis of Antibody Ligands Modified with Polyethylene Glycol
- Reaction Mechanism of Prostaglandin E_2 Biosynthesis and Its Modeling
- Effective Purification of Bioproducts by Fast Flow Affinity Chromatography
- Effects of Antigen Molecular Weight on Immunoadsorption Equilibrium in Immunoaffinity Chromatography
- ABSORPTION OF CARBON DIOXIDE INTO LOADED AQUEOUS SOLUTIONS OF 2-AMINO-2-METHYL-1-PROPANOL
- Characteristics of Microblotting Assay Using Immunoloposomes(BIOCHEMICAL ENGINEERING)
- Immunoassay Using HPLAC and Fluorescence-Labeled Antibodies
- Comparison of Liposome Immune Lysis Assay (LILA) and Enzyme-Linked Immunosorbent Assay (ELISA) for Detection of Antibodies
- Application of an Optimization Algorithm for Estimating Intrinsic Kinetic Parameters of Immobilized Enzymes(BIOCHEMICAL ENGINEERING)
- KINETICS OF ABSORPTION OF CARBON DIOXIDE INTO AQUEOUS SOLUTIONS OF STERICALLY HINDERED 2-AMINO-2-METHYL-1-PROPANOL
- Immunoadsorption of Impurities Contained in Recombinant Human Serum Albumin Secreted from Yeast
- Angiotensin-I Converting Enzyme (ACE) Inhibitory Mechanism of Tripeptides Containing Aromatic Residues
- SOLUBILITIES OF GASES IN AQUEOUS SOLUTIONS OF WEAK ACIDS
- Single and simultaneous absorptions of lean SO2 and NO2 into aqueous slurries of Ca(OH)2 or Mg(OH)2 particles.
- Movement of interface at breaking of bubble on water surface.
- Refolding Efficiency of Lysozyme in Fed-Batch System.
- GAS ABSORPTION ACCOMPANIED BY A TWO-STEP REVERSIBLE AND IRREVERSIBLE CONSECUTIVE REACTION INTO FINITE LIQUID:VARIATION OF THE ENHANCEMENT FACTOR WITH THE ORDER OF REACTION
- Interfacial turbulence during absorption with reaction.
- Performance of multistage operation in affinity chromatography.
- Rates of mass transfer in affinity chromatography.
- Performance of a membrane-type enzyme reactor utilizing ultrafiltration.
- Purification of tyrosyl-tRNA synthetase by affinity chromatography.
- Computational study of the simultaneous chemical absorption of two gases based on the penetration model.
- SOLUBILITY OF GASES IN AQUEOUS SOLUTIONS OF MIXED SALTS
- ISOTHERMAL VAPOR-LIQUID EQUILIBRIUM DATA OF ISOPROPANOL-WATER SYSTEM
- SALT EFFECTS ON VAPOR-LIQUID EQUILIBRIUM OF ISOPROPANOL-WATER SYSTEM
- Kinetics of absorption of sulfur dioxide and nitric oxide in aqueous mixed solutions of sodium chlorite and sodium hydroxide.
- GAS ABSORPTION ACCOMPANIED BY AN INSTANTANEOUS IRREVERSIBLE CHEMICAL REACTION IN LIOUID OF A FINITE DEPTH
- Methane chlorination in molten salts with use of a bubble column reactor.
- SALTING-OUT PARAMETERS OF GAS SOLUBILITY IN AQUEOUS SALT SOLUTIONS
- Engineering aspects of bioaffinity separation.
- Lysis rates of fibrin clot by plasmin.