Synthesis of Novel 25-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activity against Tetranychus urticae
スポンサーリンク
概要
- 論文の詳細を見る
Novel 25-substituted milbemycin A_4 derivatives were synthesized from 25a-hydroxymilbemycin A_4 and 25b-hydroxymilbemycin A_4, which had been obtained by the microbial oxidation of milbemycin A_4. The acaricidal activity of each synthesized derivative was tested against Tetranychus urticae, and all of the synthesized derivatives showed higher activity than parent milbemycin A_4. Some of the derivatives had higher acaricidal activity than milbemycin D, which had higher acaricidal activity than milbemycin A_4. Among them, 25b-methylmilbemycin A_4 was the most active derivative, with 100% mortality of the mite at a concentration of 1 ppm, and 63% mortality at 0.1 ppm.
- 社団法人日本農芸化学会の論文
- 1997-10-23
著者
-
Nakagawa H
Graduate School Of Science And Technology Chiba University
-
Nakagawa H
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
-
Nakagawa Hiroki
Fac.hort Chiba Univ.
-
Nakagawa Hiroki
Dep. Of Applied Biochemistry And Food Sciences Fac. Of Agriculture Saga Univ.
-
Sato K
Department Of Food Sciences And Nutritional Health Kyoto Prefectural University
-
KAJINO HISAKI
Process Development Laboratories, Sankyo. Co., Ltd.
-
TSUKAMOTO YOSHIHISA
Agroscience Research Laboratories, Sankyo Co., Ltd.
-
NAKAGAWA HARUMI
Agroscience Research Laboratories, Sankyo Co., Ltd.
-
YANAI TOSHIAKI
Agroscience Research Laboratories, Sankyo Co., Ltd.
-
SATO KAZUO
Intellectual Property Department, Sankyo Co., Ltd.
-
TANAKA KEIJI
Agroscience Research Laboratories, Sankyo Co., Ltd.
-
KAJINO HISAKI
Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd.
-
SATO KAZUO
Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd.
-
Tsukamoto Y
Agroscience Research Laboratories Sankyo Co. Ltd.
-
Tsukamoto Yoshihisa
Agroscience Research Laboratories Sankyo Co. Ltd.
-
Kajino H
Process Development Laboratories Sankyo. Co. Ltd.
-
Kajino Hisaki
Agroscience Research Laboratories Sankyo Co. Ltd.
-
Tsukamoto Yoshinori
Centeral Research Institute Mitsukan Group
-
Yanai Toshiaki
Agroscience Research Laboratories Sankyo Co. Ltd.
-
Sato K
Intellectual Property Department Sankyo Co. Ltd.
-
Sato Kazuo
Agroscience Research Laboratories Sankyo Co. Ltd.
関連論文
- A Nitrate Reductase Inactivator Protein from Spinach. Purification, Molecular Weight and Subunit Composition
- Expression of HSP70 in response to heat-shock and its cDNA cloning from Mediterranean blue mussel
- Isolation and molecular characterization of a SoWRKY1 transcription factor from spinach (Spinacia oleracea)
- Factors Improving L-Threonine Production by a Three L-Threonine Biosynthetic Genes-amplified Recombinant Strain of Brevibacterium lactofermentum
- High Fermentative Production of L-Threonine from Acetate by a Brevibacterium flavum Stabilized Strain Transformed with a Recombinant Plasmid Carrying the Escherichia coli thr Operon
- Application of a Recombinant Plasmid Expressing Desensitized 3-Deoxy-D-Arabinoheptulosonate-7-Phosphate Synthase to the Breeding of L-Phenylalanine Producers
- Improvement in Microbial Production of L-Tyrosine by Gene Dosage Effect of AroL Gene Encoding Shikimate Kinase(Microbiology & Fermentation Industry)
- Cloning and Characterization of Genes Responsible for m-Fluoro-D,L-phenylalanine Resistance in Brevibacterium lactofermentum(Microbiology & Fermentation Industry)
- Genetic Breeding of L-Tyrosine Producer from Brevibacterium lactofermentum(Microbiology & Fermentation Industry)
- Improvement of an L-Threonine Producer Derived from Brevibacterium flavum Using Threonine Operon of Escherichia coli K-12(Microbiology & Fermentation Industry)
- Effects of Japanese Black Tea on Atherosclerotic Disorders
- Inhibitory Effect of Green Tea on Injury to a Cultured Renal Epithelial Cell Line, LLC-PK_1
- Inhibition of Proteasome by MG-132 Treatment Causes Extra Phragmoplast Formation and Cortical Microtubule Disorganization during M/G_1 Transition in Synchronized Tobacco Cells
- Overexpression of a gene for 26S proteasome subunit RPN10 confers enhanced resistance to canavanine, an analog of arginine, in transgenic rice (Oryza sativa L.)
- Cell-cycle-related variation in proteins in suspension-cultured rice cells
- Cell-Cycle Dependent Dynamic Change of 26S Proteasome Distribution in Tobacco BY-2 Cells
- RECONSTRUCTION ( in vitro ) OF 20S PROTEASOME AND REGULATORY SUBUNITS FROM THE CULTURED RICE ( Oriza sativa) CELLS
- Cloning and Sequencing of cDNA from Oryza sativa encoding a homolog to non-ATPase subunit,MBP1, of 26S Proteasome in Arabidopsis thaliana
- PURIFICATION AND CHARACTERIZATION OF A 26S PROTEASOME FROM THE CULTURED RICE (Oriza sativa)CELLS
- Changes in Proteasome Levels in Spinach (Spinacia oleracea) Seeds during Imbibition and Germination
- Identification of β and γ Subunits of Laminins Localized in the Basement Membrane of Rat Circumvallate Papillae(Biochemistry & Molecular Biology)
- Changes in Cell Morphology and Cell-to-cell Adhesion Induced by Extracellular Ca^ in Cultured Taste Bud Cells(Biochemistry & Molecular Biology)
- Antimutagenic and Anticarcinogenic Properties of Kyo-yasai, Heirloom Vegetables in Kyoto
- Prolonged intake of fermented soybean (natto) diets containing vitamin K_2 (menaquinone-7) prevents bone loss in ovariectomized rats
- Effect of vitamin K_2 (menaquinone-7) in fermented soybean (natto) on bone loss in ovariectomized rats
- CLONING AND CHARACTERIZATION OF AUXIN-RESPONSIVE ACC SYNTHASE GENES FROM MELON
- ETHYLENE FORMATION IN MELON FRUITS DURING THE EARLY STAGE OF RIPENING
- CLONING OF cDNAs FOR AUXIN INDUCED1-AMINOCYCLOPLOPANE-1-CARBOXYLATE (ACC) SYNTHASE FROM ETIOLATEDSEEDLINGS OF MELON
- ETHYLENE FORMATION IN SEEDS DURINGGROWING OF MELON FRUITS
- AUXIN-RESPONSE ELEMENTS IN MELON ACC SYNTHASE GENE (CMe-ACS2) PROMOTER
- CLONING AND EXPRESSION ANALYSIS OF NITRATE REDUCTASE INACTIVATOR (NRI) GENE FROM SPINACH
- The Synthesis of Ethylene in Melon Fruit during the Early Stage of Ripening : GROWTH AND DEVELOPMENT
- Intercellular Localization of Acid Invertase in Tomato Fruit and Molecular Cloning of a cDNA for the Enzyme
- Purification and Some Properties of Acid Invertase of Persimmon Fruits
- Acid Invertase of Melon Fruits : Immunochemical Detection of Acid Invertases : GROWTH AND DEVELOPMENT
- Control by Glutamine of the Synthesis of Nitrate Reductase in Cultured Spinach Cells : PROTEINS, ENZYMES AND METABOLISM
- Size and Levels of mRNA for Acid Invertase in Ripe Tomato Fruit
- Immunological Characterization of Nitrate Reductase in Different Tissues of Spinach Seedlings
- Polygalacturonase mRNA of Tomato : Size and Content in Ripe Fruits
- Cell-Free Synthesis of a Putative Precursor of Polygalacturonase in Tomato Fruits
- Effect of Heat Treatment on the Development of Polygalacturonase Activity in Tomato Fruit during Ripening
- Monoclonal Antibodies Spicific for NADH-Ferricyanide Reductase Domain of Spinach Leaf Nitrate Reductase
- Inhibition of Pancreatic Carcinogenesis by Shark Cartilage Proteoglycan in Hamsters
- Evidence for the Existence of a Soybean Resistant Protein That Captures Bile Acid and Stimulates Its Fecal Excretion
- cDNA cloning of Japanese oyster stress protein homologous to the mammalian 78-kDa glucose regulated protein and its induction by heatshock
- Effect of Kiwifruit Juice on Beef Collagen
- Solubilization of type I collagen from fish muscle connective tissue by matrix metalloproteinase-9 at chilled temperature
- Simple and rapid chromatographic purification of type V collagen from a pepsin digest of porcine intestinal connective tissue, an unmanageable starting material for conventional column chromatography
- cDNA cloning and characterization of two gelatinases from Japanese flounder
- Cloning and characterization of cDNA for carp matrix metalloproteinase 9
- Possible implication of metalloproteinases in post-mortem tenderization of fish muscle
- DNA Repair Effect of Traditional Sweet Pepper Fushimi-togarashi : Seen in Suppression of UV-induced Cyclobutane Pyrimidine Dimer in Human Fibroblast
- Induction of gelatinolytic activities in ayu muscle at the spawning stage
- Gelatinolytic Activities in Ayu Muscle in the Spawning Stage
- cDNA Cloning of Heat-inducible HSP70, a 70.6kDa Heat Shock Protein, in Japanese Flounder Paralichtys olivaceus
- Comparative Bio-antimutagenicity of Common Vegetables and Traditional Vegetables in Kyoto
- Occurrence of Gelatinolytic Activities in Yellowtail Tissues
- Effect of Steroid Hormone Administration on the Breakdown of Muscle Proteins in Ayu
- Complementary DNA Cloning of HSC71, a 71 kDa Heat Shock Cognate Protein, in Japanese Flounder Paralichtys olivaceus
- Enzymatic Properties,Substrate Specificities and pH-Activity Profiles of Two Kiwifruit Proteases
- Effect of Maturation on the Contents of Free and Bound Forms of Hydroxyproline in Ayu Muscle
- Effects of a Component of Green Tea on the Proliferation of Vascular Smooth Muscle Cells
- Isolation and Characterization of Cytotoxic Compounds from Corn
- Synthesis of Novel 26-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activities
- Synthesis and Insecticidal Activity of Novel N-Oxydihydropyrrole Derivatives with a Substituted Spirocyclohexyl Group(Organic Chemistry)
- Synthesis of Milbemycins α_9, α_, α_, α_, α_, α_, α_, α_, α_, α_, α_, α_, Δ^, Δ^-Milbemycins A_3, A_4, from Milbemycins A_3, A_4, and Their Acaricidal Activities
- Synthesis and Insecticidal Activity of N-Oxydihydropyrroles : 4-Hydroxy-3-mesityl-5, 5-dimethyl Derivatives with Various Substituents at the 1-Position(Organic Chemistry)
- Synthesis of 27-Oxo, 27-Hydroxymilbemycins A_3 and A_4 and Novel 27-Alkoxymilbemycins A_3 and A_4 from Milbemycins A_3 and A_4 and Their Acaricidal Activities(Organic Chemistry)
- New Milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus : Fermentation, Isolation and Structure Elucidation
- Development of a novel lepidopteran insect control agent, chromafenozide(Society Awards 2006(on prominent achievement))
- Prolonged Intake of Dietary Fermented Soybeans(Natto) with the Reinforced Vitamin K_2 (Menaquinone-7) Enhances Circulating γ- Carboxylated Osteocalcin Concentration in Normal Individuals
- Intake of fermented soybean (natto) increases circulating vitamin K_2 (menaquinone-7) and γ-carboxylated osteocalcin concentration in normal individuals
- Synthesis of Novel 25-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activity against Tetranychus urticae
- Synthesis of 24a-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activity against Tetranychus urticae
- Synthesis of 5-Deoxy-5-oxomilbemycin A_4 5-Hydrazone Derivatives and Their Activity against Tetranychus urticae
- Syntheses of 8,9-Epoxy-and5-O-Acyl-8,9-epoxymilbemycin A_4 and Their Activity against Tetranychus urticae
- Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and Their Activities against Microfilariae(Organic Chemistry)
- Milbemycin α_17 and Related Compounds Synthesized from Milbemycin A_4 : Synthetic Procedure and Acaricidal Activities
- Synthesis of Milbemycins β_9 and β_ from Milbemycins A_3 and A_4 and Their Biological Activities(Organic Chemistry)
- Activation of the 20S Proteasome of Xenopus Oocytes by Cardiolipin : Blockage of the Activation of Trypsin-like Activity by the Substrate
- Efficient N-Sulfenylation of Dihydropyrrole Derivatives Using N-Sulfenylphthalimides
- Synthesis of N-Oxydihydropyrrole Derivatives
- Quantitative Anhydrous Mercaptolysis of Algal Galactans Followed by HPLC of Component Sugars
- Purification and Characterization of the Alkaline Serine Protease Produced by Bacillus sp.N4 Strain from Fish Skin Mucus
- Microbial Conversion of Milbemycins:Oxidation of Milbemycin A_4 and Related Compounds at the C-25 Ethyl Group by Circinella umbellata and Absidia cylindrospora
- Inhibition by Bovine Lactoferrin of Adhesion of L929 Cells Cultured in Serum-free GIT Medium
- Uptake and Re-secretion of Human Lactoferrin by B Lymphocytes(Biological Chemistry)
- Activation of the 20S Proteasome of Xenopus Oocytes by SDS : Evidence for the Substrate-Induced Conformational Change Characteristic of Trypsin-Like Peptidase
- Irreversible Potent Activation and Reversible Inhibition of Trypsin-Like Activity of 20S Proteasome Purified from Xenopus Oocytes by Fatty Acid
- Purification and Characterization of Six Kiwifruit Proteases Isolated with Two Ion-exchange Resins, Toyopearl-SuperQ and Bakerbond WP-PEI
- Purification and Characterization of Glycoprotein from the Skin Mucus of the Rainbow Trout, Salmo gairdneri
- Structural Characterization of the Carbohydrate Chains from the Skin Mucus Sialoglycoprotein of the Stingray Dasyatis akajei
- Isolation and Properties of a Sialoglycoprotein from the Skin Mucus of the Stingray Dasyatis akajei
- Purification and Characterization of Glutaredoxin (Thioltransferase) from Rice (Oryza sativa L.)^1
- PC81 THE SYNTHESIS OF 5-KETO-5-OXIME DERIVATIVES OF MILBEMYCINS AND THEIR ACTIVITIES AGAINST MICROFILARIAE
- Selective Hydrolysis of the 3,6-Anhydrogalacotosidic Linkage in Red Algal Galactan : A Combination of Reductive Acid Hydrolysis and Anhydrous Mercaptolysis
- Simulation Study on Oxygen Uptake Rate of Immobilized Growing Microorganisms
- Degradation of α-Connectin in Raw Fish Muscle and Softening Evaluated by the Breaking Strength Occur Independently during One Day-chilled Storage
- Improved chromatographic purification of human and bovine type V collagen sub-molecular species and their subunit chains from conventional crude preparations : Application to cell-substratum adhesion assay for human umbilical vein endothelial cell
- Enzymatic Properties, Substrate Specificities and pH-Activity Profiles of Two Kiwifruit Proteases