Syntheses of 8,9-Epoxy-and5-O-Acyl-8,9-epoxymilbemycin A_4 and Their Activity against Tetranychus urticae

スポンサーリンク

概要

• 論文の詳細を見る

• To improve the acaricidal activity of milbemycins, 8, 9-epoxymilbemycin A_4 (3) and 5-O-acyl-8, 9-epoxymilbemycin A_4 (7) were synthesized by using selective epoxidation of the 8, 9-double bond. The acaricidal activity against the two-spotted spider mite (Tetranychus urticae) was slightly improved by 8, 9-epoxidation of milbemycin A_4 (1b). while acylation of 8, 9-epoxymilbemycin A_4 (3) markedly enhanced its activities. Some 5-O-acylated 8, 9-epoxides totally controlled the mites at a concentration of 3ppm.

• 社団法人日本農芸化学会の論文
• 1995-02-23

著者

• Kinoto Takao

  Agroscience Research Laboratories Sankyo Co. Ltd.

• TSUKAMOTO YOSHIHISA

  Agroscience Research Laboratories, Sankyo Co., Ltd.

• YANAI TOSHIAKI

  Agroscience Research Laboratories, Sankyo Co., Ltd.

• SATO KAZUO

  Intellectual Property Department, Sankyo Co., Ltd.

• SATO KAZUO

  Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd.

• Tsukamoto Y

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Tsukamoto Yoshihisa

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Nishida Akira

  Agroscience Research Laboratories, Sankyo Co. Ltd.

• Tanaka Keiji

  Agrochemicals Development and Technical Services Department, Sankyo Co. Ltd.

• Naito Satoru

  Medicinal Chemistry Research Laboratories, Sankyo Co. Ltd.

• Ide Junya

  Medicinal Chemistry Research Laboratories, Sankyo Co. Ltd.

• Ide Junya

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Naito Satoru

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Tsukamoto Yoshinori

  Centeral Research Institute Mitsukan Group

• Yanai Toshiaki

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Sato K

  Intellectual Property Department Sankyo Co. Ltd.

• Nishida Akira

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Sato Kazuo

  Agroscience Research Laboratories Sankyo Co. Ltd.

関連論文

• Identification of β and γ Subunits of Laminins Localized in the Basement Membrane of Rat Circumvallate Papillae(Biochemistry & Molecular Biology)
• Changes in Cell Morphology and Cell-to-cell Adhesion Induced by Extracellular Ca^ in Cultured Taste Bud Cells(Biochemistry & Molecular Biology)
• Prolonged intake of fermented soybean (natto) diets containing vitamin K_2 (menaquinone-7) prevents bone loss in ovariectomized rats
• Effect of vitamin K_2 (menaquinone-7) in fermented soybean (natto) on bone loss in ovariectomized rats
• Synthesis of Novel 26-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activities
• Synthesis of Milbemycins α_9, α_, α_, α_, α_, α_, α_, α_, α_, α_, α_, α_, Δ^, Δ^-Milbemycins A_3, A_4, from Milbemycins A_3, A_4, and Their Acaricidal Activities
• Synthesis and Herbicidal Activity of 1,5-Diarylpyrazole Derivatives
• A Novel Synthesis of 4H-1,4-Benzoxazines
• A Novel Synthesis of 3-Aryl-5-tert-butyl-4-oxazolin -2-ones
• Synthesis of 27-Oxo, 27-Hydroxymilbemycins A_3 and A_4 and Novel 27-Alkoxymilbemycins A_3 and A_4 from Milbemycins A_3 and A_4 and Their Acaricidal Activities(Organic Chemistry)
• New Milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus : Fermentation, Isolation and Structure Elucidation
• Development of a novel lepidopteran insect control agent, chromafenozide(Society Awards 2006(on prominent achievement))
• Prolonged Intake of Dietary Fermented Soybeans(Natto) with the Reinforced Vitamin K_2 (Menaquinone-7) Enhances Circulating γ- Carboxylated Osteocalcin Concentration in Normal Individuals
• Intake of fermented soybean (natto) increases circulating vitamin K_2 (menaquinone-7) and γ-carboxylated osteocalcin concentration in normal individuals
• Synthesis of Novel 25-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activity against Tetranychus urticae
• Synthesis of 24a-Substituted Milbemycin A_4 Derivatives and Their Acaricidal Activity against Tetranychus urticae
• Synthesis of 5-Deoxy-5-oxomilbemycin A_4 5-Hydrazone Derivatives and Their Activity against Tetranychus urticae
• Syntheses of 8,9-Epoxy-and5-O-Acyl-8,9-epoxymilbemycin A_4 and Their Activity against Tetranychus urticae
• Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and Their Activities against Microfilariae(Organic Chemistry)
• Milbemycin α_17 and Related Compounds Synthesized from Milbemycin A_4 : Synthetic Procedure and Acaricidal Activities
• Synthesis of Milbemycins β_9 and β_ from Milbemycins A_3 and A_4 and Their Biological Activities(Organic Chemistry)
• Bioconversion of Milbemycin-related Compounds: Isolation and Utilization of Non-producer, Strain RNBC-5-51
• Microbial Conversion of Milbemycins:Oxidation of Milbemycin A_4 and Related Compounds at the C-25 Ethyl Group by Circinella umbellata and Absidia cylindrospora
• Fermentative production of milbemycin α_ and α_ : Appearance of morphological mutants during large-scale fermentation
• 4-Sulfenyl-2-carbamoyl-4-isoxazolin-3-ones : Biological Isostere to 4-Chloro-2-carbamoyl-4-isoxazolin-3-ones
• PC81 THE SYNTHESIS OF 5-KETO-5-OXIME DERIVATIVES OF MILBEMYCINS AND THEIR ACTIVITIES AGAINST MICROFILARIAE
• Simulation Study on Oxygen Uptake Rate of Immobilized Growing Microorganisms
• A Practical Method for the Preparation of 4-Nitrogen-substituted Benzoic Acids
• 殺ダニ剤ミルベメクチンの開発〔含 英文〕

もっと見る 閉じる

スポンサーリンク