Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and Their Activities against Microfilariae(Organic Chemistry)

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概要

• 論文の詳細を見る

• Starting from milbemycin D (1), milbemycin A_4 (2) and milbemycin A_3 (3), a series of 5-keto-5-oxime derivatives were synthesized by selective oximation at the α, β-conjugated carbonyl function of the 5-ketomilbemycins (4-6). The activities of the synthesized compounds were studied in dogs naturally infested with microfilariae of Dirofilaria immitis. The 5-keto-5-oximes of milbemycin D (7), A_4 (8) and A_3 (9) had quite high efficacy to control the microfilariae and more potency than their parents, while the 5-O-acyl oximes (11-15) also exhibited high activity.

• 社団法人日本農芸化学会の論文
• 1991-10-23

著者

• TSUKAMOTO YOSHIHISA

  Agroscience Research Laboratories, Sankyo Co., Ltd.

• YANAI TOSHIAKI

  Agroscience Research Laboratories, Sankyo Co., Ltd.

• SATO KAZUO

  Intellectual Property Department, Sankyo Co., Ltd.

• Sugai Soji

  Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.

• Mio Shigeru

  Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.

• Tsukamoto Y

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Ide Junya

  Medicinal Chemistry Research Laboratories, Sankyo Co. Ltd.

• TSUKAMOTO Yoshihisa

  Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.

• SATO Kazuo

  Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.

• YANAI Toshiaki

  Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.

• KITANO Noritoshi

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.

• MURAMATSU Shigeki

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.

• NAKADA Yasuo

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.

• Ide Junya

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Nakada Yasuo

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Tsukamoto Yoshinori

  Centeral Research Institute Mitsukan Group

• Yanai Toshiaki

  Agroscience Research Laboratories Sankyo Co. Ltd.

• Kitano Noritoshi

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Muramatsu Shigeki

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Sato K

  Intellectual Property Department Sankyo Co. Ltd.

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