Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine(Organic Chemistry)

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概要

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• An efficient synthesis of 3-hydroxyisoxazoles from β-ketoesters and hydroxylamine was investigated. The reaction of the sodium salts of β-ketoesters and hydroxylamine at a low temperature, followed by quenching with an excess of conc. HC1 under heating gave predominantly 3-hydroxyisoxazoles involving 4-sulfenylated 3-hydroxyisoxazoles. Starting from the prepared 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole, a potential herbicidal compound, 4-(2,4-dichlorobenzoyl)-3-hydroxy-5-methylisoxazole, was also synthesized in five steps.

• 社団法人日本農芸化学会の論文
• 1986-07-23

著者

• Tomita Kazuo

  Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.

• Sugai S

  Sankyo Co. Ltd. Shiga Jpn

• Sugai Soji

  Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.

• SATO Kazuo

  Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.

• Sato K

  Osaka City Univ. Osaka Jpn

関連論文

• Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and Their Activities against Microfilariae(Organic Chemistry)
• Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine(Organic Chemistry)
• Synthesis and Herbicidal Activity of Deoxy Derivatives of (+)-Hydantocidin(Organic Chemistry)
• Synthesis and Herbicidal Activities of 1, 2-Benzisoxazole-3-acetamide Derivatives

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