NT-1 テープおよび10% Nitroglycerin (NT-1 原薬) の経皮投与による急性毒性試験

概要

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An acute toxicity of NT-1 tape was investigated in mice, rats and rabbits, and also an acute toxicity of NT-1 ointment in rabbits. An irritation of NT-1 tape was investigated in rabbits. 1. Dead animals treated with NT-1 tape or ointment were not observed in reliable maximum administration dose of 0.88 mg/body as GTN (nitroglycerin) in mice (male ; about 29.1 mg/kg, female ; about 35.2 mg/kg), of 3.96 mg/body as GTN in rats (male ; about 26.0 mg/kg, female ; about 28.9 mg/kg) and of 480 mg/kg as GTN in rabbits. 2. There were not toxic signs in mice and rats. The below findings were observed in rabbits treated mainly with NT-1 ointment: decreased spontaneous activity, decreased reactivity to various stimuli such as sound and touch, and behavior of binding food box. However, the rabbits recovered from those abnormal behavior in a day. 3. Any body weight changes and any autopsy findings attributable to NT-1 tape or ointment were not observed in mice, rats and rabbits. 4. The effects on ECG were not observed in rabbits. 5. The GTN absorption ratio in rabbits treated with NT-1 ointment was thought to be 60-70% from GTN residual ratio. 6. The skin irritation was not observed in rabbits treated with NT-1 tape.
日本トキシコロジー学会の論文
1986-05-01