Increase of Indole-3-acetic Acid in Human Esophageal Cancer Tissue
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概要
- 論文の詳細を見る
The contents of indole-3-acetic acid in the normal tissues and squamous cell carcinoma obtained from patients with esophageal cancer were determined by gas chromatography/high resolution-selected ion monitoring mass spectrometry. The contents of indole-3-acetic acid in cancer tissues were higher than those in neighboring normal tissues. The contents in normal tissues and squamous cell carcinoma are in the range of 90-390ng/g fw and in the range of 1400-4700ng/g fw, respectively. These data show that the production of indole-3-acetic acid was activated in the squamous cell carcinoma at the early differentiating stage. The increase of indole-3-acetic acid may concern the stimulation of the multiplication of esophageal cancer cells or the formation of such an inhibitor as indole-3-carbinol.
- 日本学士院の論文
著者
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Murofushi Noboru
Department Of Agricultural Chemistry The University Of Tokyo
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Yamaguchi Isomaro
Department Of Agricultural Chemistry Faculty Of Agricultural Science University Of Tokyo
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Yamaguchi I
Univ. Tokyo Tokyo Jpn
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SHIMOJO Emi
Section of Internal Medicine and Gastroenterology, International Medical Center of Japan
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MUROFUSHI Noboru
Department of Applied Biological Chemistry, The University of Tokyo
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