N-benzoyl-N'-phenyl-2,6-diaminobenzoic acid(F-1)の薬理学的研究-1-抗炎症作用

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From the screening of a number of new derivatives that have together a side chain of salicylic and anthranilic acid, the title compound, F-1, was selected as the most significant derivative for the anti-edemateous action on carrageenin induced edema. The anti-inflammatory action of F-1 was assessed by detailed analysis. Inhibitory effect of F-1 on acute inflammation (in various tests on increased vascular permeability and acute edema) was more potent than that of aspirin (AS). and similar to that of flufenamic acid (FA) and phenylbutazone (PB). F-1 was less effective than FA and PB in the inhibitory effect on ultraviolet erythema. On subacute inflammation (in tests on sustained edema, proliferation of granulation tissue and adjuvant arthritis), F-1 produced an inhibitory effect, but the activity was slightly less than that of FA and PB. F-1 also showed an anti-edemateous effect on adrenalectomized rats. This fact plus the lack of thymolytic activity suggest a direct action at inflamed sites and not one via a corticoidal intermediary. The ulcerogenic action of F-1 was weaker than that of AS, PB and FA. F-1 presumably does not have uricosuric action as it did not delay the excretion rate of phenol red in rabbits. From the above results, F-1 may be classified as a non-steroidal anti-inflammatory agent.
社団法人日本薬理学会の論文