2-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dione並びにその誘導体の抗炎症, 鎮痛及び解熱作用

概要

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The analgesic and sedative effects of tetrahydropalmatine, tetrahydroberine and tetrahydroisoquinoline derivatives have been recognized. In order to discover new derivatives of tetrahydroisoquinoline with pharmacological properties similar to tetrahydropalmatine and with a simpler, easily synthesizable structure, several new derivatives of tetrahydroisoquinoline were synthesized. They were examined for their anti-inflammatory effect and analgesic effect in mice using Whittle's method and for their antipyretic effect in rats with endotoxin. 2-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dione was found to possess equally effective anti-inflammatory and analgesic properties as the reference drug, aminopyrine. It was found that this compound at 25 mg/kg, p. o. was as effective in its antipyretic action as aminopyrine at 100 mg/kg, p. o. Among other 13 new derivatives, 2-dimethylaminoethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione was also found to possess a similar degrees of anti-inflammatory and analgesic effect as aminopyrine.
公益社団法人日本薬学会の論文
1985-03-25