The Antiulcer Action of Sophara and the Active Constituent in Sophara. II. : The Antiulcer Action of Vexibinol

概要

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The inhibitory effect of vexibinol, one of the flavanols found in Sophora, on gastric uncers induced by HCl-ethanol has been reported previously. In the present study, the effect of vexibinol was examined in various experimental ulcer models in order to determine the mechanism of its antiulcer action. The results indicated that the oral administration of vexibinol at 25-50 mg/kg significantly inhibited the development of ulcers induced by HCl-ethanol, 0.6 N HCl, 0.2N NaOH, absolute ethanol and 1% NH_3. In addition, an intraduodenal administraion of vexibinol at 300 mg/kg significantly inhibited Shay's ulcer. Further, intraduodenal administraion at 300 mg/kg significantly inhibited acid secretion caused by 2-deoxy-D-glucose. These results suggest that vexibinol has not only gastric mucosal protective action but also an inhibitory effect on the secretion of gastric acids.
社団法人日本薬学会の論文
1990-04-25