The Effect of Crude Drugs on Experimental Hypercholesteremia : Mode of Action of (-)-Epigallocatechin Gallate in Tea Leaves

概要

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The mechanism of the anti-hypercholesteremic effect of (-)-epigallocatechin gallate (EGCG), a component of green tea, was explored in rats from the viewpoint of cholesterol metabolism.1) The in vitro incorporation of ^<14>C-acetate into cholesterol was not affected by the presence of EGCG in liver slices from normal rats or by oral pretreatment of the animals with EGCG in liver slices from normal and Triton-induced hypercholesteremic rats.2) The kinetics of serum levels of ^<14>C-cholesterol given orally and of ^3H-cholesterol given intravenously revealed that EGCG, when orally administered, suppressed the absorption of ^<14>C-cholesterol from the digestive tract and had an enhancing effect on elimination of serum ^3H-cholesterol at higher doses.3) In situ uptake in the intestine of ^<14>C-choresterol given in the lumen was suppressed by the presence of EGCG.In conclusion, these results indicated that the anti-hypercholesteremic effect EGCG in rats is mainly due to suppression of the absorption of exogenous cholesterol from the digestive tract, and partly due to the enhancement of the elimination of endogenous cholesterol.
社団法人日本薬学会の論文
1988-01-25