生姜修治の薬理学的解明.I. : Gingerol類及びShogaol類の抗アレルギー活性及び強心活性

概要

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In order to study the effects of processing of ginger (Zingiberis Rhizoma) on its pharmacological activities the in vivo and in vitro antiallergic activities and chemical constituents of methanolic extracts from fresh rhizomes and dry rhizomes of Zingiber officinale Roscoe were assayed. 6- and 8-shogaols and 8-gingerol showed dose-dependent inhibitory activities on the histamine release from rat peritoneal mast cells induced by a compound, 48/80 and a calcium ionophore, A23187 in vitro, whereas 6- and 10-gingerols and other tested compounds from fresh ginger showed no obvious inhibitory activity. Furthermore, 6-shogaol and 6-gingerol were found to exhibit an inhibitory activity on the 48 h-passive cutaneous anaphylaxis (PCA) in vivo test in rat sensitized with mouse monoclonal IgE. The inotropic effects of 6- and 8-shogaols on the isolated left atria of guinea pigs were compared with those of 6- and 8-gingerol. 6- and 8-shogaol were found to show a positive inotropic activity of about the same potency as that of 8-gingerol.
日本生薬学会の論文
1995-03-20