SAUSSUREAMINES A, B, C, D, AND E, NEW ANTI-ULCER PRINCIPLES FROM CHINESE SAUSSUREAE RADIX
スポンサーリンク
概要
- 論文の詳細を見る
Five new amino acid-sesquiterpene adducts, saussureamines A, B, C, D, and E, were isolated from Chinese Saussureae Radix, the dried root of Saussurea lappa CLARKE, together with a new lignan glycoside, (-)-massoniresinol 4"-O-β-D-glucopyranoside. Their structures were determined on the basis of chemical and physicochemical evidence. Among of these compounds. saussureamines A, B, C showed anti-ulcer effect on HCl / ethanol-induced lesions in rats, and saussureamine A also exhibited a inhibitory activiity on stress-induced ulcer formation in mice. During the course of these studies, facile conversion from sesquiterpene having an α-methylene γ-lactone function to amino acid-sesquiterpene adduct has been accomplished by means of Michael type addition reaction.
- 公益社団法人日本薬学会の論文
- 1993-01-15
著者
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山原 條二
京都薬科大学生薬学教室
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山原 條二
Kyoto Pharmaceutical University
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畠山 祥子
Kyoto Pharmaceutical University
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井上 泰尚
Kyoto Pharmaceutical University
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