生姜の健胃作用成分(第2報)台湾産生姜(Zingiberis Rhizoma)脂溶性成分の辛味及び抗潰瘍作用.新規ジアリルヘプタノイドの化学構造

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By using the effects on HCl/ethanol-induced gastric lesions in rats, β-sesquiphellandrene (2), β-bisabolene (3), ar-curcumene (4) and 6-shogaol (5) were isolated as anti-ulcer active principles in ginger, the dried rhizoma of Zingiber officinale ROSCOE (Shokyo in Japanese) which was cultivated in Taiwan, together with nine known compounds and a new diarylheptanoid. The absolute stereostructure of the diarylheptanoid was characterized as (3S, 5S)-dihydroxy-1-(4'-hydroxy-3', 5'-dimethoxyphenyl)-7-(4"-hydroxy-3"-methoxyphenyl) heptane (15) on the basis of chemical and spectroscopic evidence which included the application of the benzoate chirality method. The pungent effects of several constituents isolated from ginger were examined.
1992-09-25