組織透過性にたいする諸種薬物の影響(III)ビタミンB_1およびその誘導体の単独および各種抗炎症剤との併用効果

概要

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The effect of thiamine and its derivatives (TPD, TTFD, TDS, BuTDS and CCT) on the dermal connective tissue permeability in rats were tested by means of spreading method. Subsequently the effect of various anti-inflammatory agents combined with these vitamins on the tissue permeability were also tested. (1) Of these vitamins, TTFD only decreased significantly the tissue permeability with subcutaneous or oral administration. (2) When Na-salicylate was combined with several graded doses of thiamine and its derivatives, its inhibitory effect was reached to peak in combination with a dose of 100mg/kg s.c. or 200 mg/kg p.o. of thiamine, whereas a dose of 25 mg/kg s.c. or 50mg/kg p.o. of TPD or CCT and 10mg/kg s.c. or 20 mg/kg p.o. of TTFD. (3) When various anti-inflammatory agents were combined with either vitamin described above, the potentiations of the inhibitory effect of them were observed.
日本ビタミン学会の論文
1969-04-25