冠動脈造影検査に伴う低浸透圧ヨード造影剤の副作用発現率とその危険因子の検索

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The purpose of this study was to assess the incidence of the adverse reactions of low-osmolar non-ionic contrast media and its risk factors in patients receiving this contrast media for coronary angiography. We investigated all clinical data of 1 386 patients who received non-ionic contrast media(Iopamidol, Iomeprol) from September 1995 to August 1996 for coronary angiography. The overall incidence of the adverse reactions of the drug was 31.5%, but there were no severe or fatal adverse reactions. The predominant adverse reactions were nausea (20.8%) and vomiting (12.2%). The Incidence of the adverse reactions in females (51.9%) was definitely higher than that in males (24.7%). In females in the menopause age period, the incidence of adverse reactions occurred at rate of 69.8%, while in females in the non-menopause age, its incidence occurred at a rate of only 43.2%. The incidence of the adverse reactions was much higher in the patients who had a history of allergy, renal impairment or previous adverse reactions to the contrast media. In addition, adverse reactions In the patients undergoing a coronary spasm test were also observed at a higher frequency. Furthermore, it was shown that the incidence of a delayed-reactions to the drug was 8.7% (12 patients). These findings suggest that the monitoring of the adverse reactions after patients ingest a low-osmolar iodine contrast media is a necessary in order to acute adverse reactions as nausea and vomiting, as well as any delayed-reactions that may be induced by this contrast media. Furthermore, we propose that the menopause, which is peculiar to females may also be one of the risk factors for an increased occurrence of adverse reactions to this contrast media.
日本医療薬学会の論文
1998-12-10

冠動脈造影検査に伴う低浸透圧ヨード造影剤の副作用発現率とその危険因子の検索

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