和漢薬方剤の利水作用に関する薬理学的研究 : その薬理学スクリーニングの応用と評価

概要

論文の詳細を見る
According to clinical observation, three Wakan-yaku formulations: Hoki-kenchu-to (Bu-Qi-Jian-Zhong-Tang, TJS-210) ; Hochu-jisitsu-to (Bu-Zhong-Zhi--Si-Tang, TJS-213) ; Boi-to (Fang-Ji-Tang, TJS-217) could be beneficial in patients with edema disorder such as chronic renal disease, cirrhosis and congestive heart failure. So far, no experimental study has been done for these formulations. Briefly, we put the main focus on their diuretic activity. Normal rats and various pathological models were used for analysis. The present investigation has documented that the three formulations, TJS-210, TJS-213 and TJS-217 possess diuretic activity in normal rats and diseased models. Especially, TJS-210, TJS-213 and TJS-217 showed diuretic activity in normal rats. All formulations except TJS-213 significantly in-creased urine volume in rats with puromycin aminonucleoside-induced nephrosis. The diuretic activity of all formulations in hepatic damage model by CCl_4 were presented, two of which, TJS-210 and TJS-217, also tend to decrease serum GPT and GOT levels. Although the diuretic action of all formulations in the nephritic rats with anti-GBM nephritis was not evident, TJS-210 significantly decreased serum urea nitrogen levels. These results confirmed that all formulations have significant diuretic effect, which is dependent on the proper dose and the pathophysiology of the edematous disorders. That is, an effective match of optimal dose (no dose-dependent fashion) and pathophysiologic state is essential in order to exert diuretic action of the four formulations. These findings were thought to be important approaches for screening and studying pharmacodynamics of traditional medicine.
和漢医薬学会の論文
2000-06-30

和漢薬方剤の利水作用に関する薬理学的研究 : その薬理学スクリーニングの応用と評価

スポンサーリンク

概要

著者

関連論文

スポンサーリンク