細胞死現象に基ずいた貧血形態の分類,細胞増殖と分化とアポトーシス,および,成熟赤血球の細胞死

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A classification of types of anemia on the basis of the cell death phenomena is proposed. The proposed classification accounts for recent developments in studies of hemopoietic mechanisms and new formulae for specifying cell death. Cell-proliferation, cell-differentiation, and -apoptosis are understood to be divided into two different processes : cell proliferation accompanied by or not accompanied by cell differentiation. However, apoptosis is only frequent, when cell proliferation is accompanied by differentiation. In anemia, apoptosis of immature cells in bone marrow may be incited by : disturbance of the bone marrow microenvironment, decreased suppy of cell growth factors and hemopoietic factors, excess production of negtive regulators of hemotopoiesis, lack of nutritious elements, inhibition of heme synthesis, and others. Destruction of senescent red cells does constitute a type programmed cell death which, however, has been found to be different from patterns of apoptosis. Hemolytic anemia may be caused by mechanical damage, complement-mediated cell lysis, and highly toxic agents. Therefore, hemolysis may be classified to belong to the cell death type necrosis. However, mature red cells donot contain lysozomes which would give rise to inflammation. This provides justification for thinking that hemolysis of mature red cells shoud be differentiated from cell necrosis which is accompanied by inflammation of tissue. The authors propose a classification of necrosis followed by inflammation as type I necrosis, while hemolysis which is not followed by inflammation is considered as type II necrosis.
北海道医療大学の論文
1999-06-30

細胞死現象に基ずいた貧血形態の分類,細胞増殖と分化とアポトーシス,および,成熟赤血球の細胞死

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