<原報>ビタミンB_1およびその関連化合物の薬理作用

概要

論文の詳細を見る
Following experiments were made mainly about the effects of VB_1 and its related compounds on the action and synthesis of ACh. 1) The ACh-induced contraction of isolated ileum of guinea pigs was increased by the pretreatment of these examined substances. 2) Inhibitory effect of examined substances on ChE of horse's serum was found only in a high concentration. 3) The formation of free and total ACh in chopped tissue of frog's brain was increased with a low concentration of examined substances. The order of intensity was as follows : TPD>TPP> VB_1. 4) In the contraction of rat's phrenic nerve-diaphram preparation by indirect stimulation, these substances showed a decrease seems to be a curare-like action in a concentration of 5×l0^<-3>M, but an increase in l0^<-3>M. Their potentiation for the contraction was more remarkable by the pretreatment of DFP, one of potent cholinesterase inhibitors, or in the fatigued preparation. On the other hand, the effect of these substances was somewhat or little in the contraction by direct stimulation. 5) Analgesic activity of these substances was found somewhat or little in rabbits subjected to dental pulp-stimulation method. 6) These substances didn't affect the ED_<50> value of morphine in mice.
岐阜薬科大学の論文
1971-06-30