実験的nephrotic ratに関する薬理学的研究 : (第1報)抗ラット腎家兎血清投与によるrat nephfosisの発症と腎酵素活性の変化

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When anti-rat kidney serum obtained from rabbits by Heymanns method was administered intravenously (1.4ml/100g B. W.×1/3×3 days) to rats, the following syndrome was induced. 1) Strong proteinuria was produced immediately and continued for 30 days at a high level. Excretion of alkaline phosphatase (AP) and lactic dehydrogenase (LDH) in urine significantly increased, while Na+ excretion decreased. 2) In addition to the appearance of hypoproteinemia and decrease of AP activity in blood, hyperlipemia and the elevations of blood urea nitrogen, creatinine and LDH activity were observed at an early stage. 3) On the other hand, protein concentration and AP activity in whole kidney homogenate diminished, whereas a significant increase of glucose-6-phosphate dehydrogenase activity was recognized for 20 days while that of LDH activity was weakly. 4) Considerable retention of ascites and kidney hypertrophy were observed as serious at autopsy.
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