Lysyl-Aspartic Acid Derivatives as Model Compounds of Growth Hormone to Induce Lipolysis(Biological Chemistry)

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概要

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• The effects of derivatives containing Lys-Asp sequences on growth-hormone-mediated lipolysis were examined for fat cells isolated from rat epididymal adipose tissue. A dipeptide, Lys-Asp, had a weak but distinct ability to induce lipolysis and inhibit growth-hormone-mediated lipolysis. Among the derivatives tested, Lys(Z)-Asp(OEt)-OEt (6d), Lys(Z)-Asp(OC_4H_9)-OC_4H_9 (6e), Lys(Z)-Asp(OC_8H_<17>)-OC_8H_<17> (6f), C_7H_<15>CO-Lys(Z)-Asp (4b), and C_<15>H_<31>CO-Lys(Z)-Asp (4c) had a fairly high lipolytic activity. The derivatives 6e, 6d and 4c inhibited growth-hormone-mediated lipolysis. A derivative, C_<15>H_<31>CO-Lys-Asp(Ome)-Ome (3c), had no lipolytic activity but strongly inhibited for growth-hormone-mediated lipolysis. It is suggested that charge groups in the Lys-Asp derivatives are responsible for lipolytic action and the hydrophobic hydrocarbon chains in the derivatives enhance the ability to induce lipolysis or inhibit the gorwth-hormone-mediated lipolysis.

• 社団法人日本農芸化学会の論文
• 1988-03-23

著者

• YAMASAKI Nobuyuki

  Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University

• IDE Akio

  Laboratory of Biochemistry, Faculty of Agriculture, Yamaguchi University

• Yamasaki Nobuyuki

  Laboratory Of Biochemistry And Laboratory Of Protein Chemistry And Engineering Faculty Of Agricultur

• MASUNO Hiroshi

  Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health

• Okuda H

  Division Of Food And Health Environment Faculty Of Environmental And Symbiotic Science Prefectural U

• Okuda H

  Department Of Medical Biochemistry School Of Medicine Ehime University

• Ide Akio

  Laboratory Of Biochemistry Faculty Of Agriculture Yamaguchi University

• Masuno Hiroshi

  Department Of Medical Laboratory Technology Ehime College Of Health Science

• OKUDA Hiromichi

  Department of Medical Biochemistry, School of Medicine, Ehime University

• Okuda Hiromichi

  Department Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Yamasaki Nobuyuki

  Laboratory Of Agricultural Process Engineering Faculty Of Agriculture Kyushu University

• Masuno Hiroshi

  Department of Medical Laboratory Technology, Ehime College of Health Science

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