Ginsenosides Increase Secretion of Lipoprotein Lipase by 3T3-L1 Adipocytes

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Treatment of 3T3-L1 adipocytes with either an oleanolic acid glycoside or a 20(S)-protopanaxatriol glycoside increased the secretion of lipoprotein lipase activity into the medium dose-dependently. At a concentration of 100 μg/ml, ginsenosides Ro, Re, Rg_1, and Rh_1 increased the secretion of lipase activity into the medium by 119, 107, 56, and 32%, respectively. The ratio of lipase activity in the medium to cellular lipase activity was 4.7% in control cells and 8.6% in ginsenoside Ro-treated cells, 8.3% in ginsenoside Re-treated cells, 7.0% in ginsenoside Rg_1-treated cells, and 6.3% in ginsenoside Rh_1-treated cells. Ginsenoside Rb_2, which is a 20(S)-protopanaxadiol glycoside, increased the secretion of lipase activity by 16% at 25 μg/ml, and the ratio of lipase activity in the medium to cellular lipase activity was higher in ginsenoside Rb_2-treated cells than in control cells. However, at 100 and 200 μg/ml, ginsenoside Rb_2 decreased the secretion of lipase activity in parallel with cellular lipase activity. Ginsenoside Rd also decreased the secretion of lipase activity in the same dose-dependent manner. Thus, the effective dose for the secretion of lipoprotein lipase activity with ginsenosides varies with their aglycone structure.
社団法人日本農芸化学会の論文
1996-12-23