Studies on the Mechanism of Action of ACTH on Triglyceride Synthesis in Fat Cells
スポンサーリンク
概要
- 論文の詳細を見る
It was found that ACTH greatly reduced lipogenesis in fat cells in the presence of calcium ion, but not in the absence of calcium ion. Of the enzymes involved in triglyceride synthesis from fatty acid in lipid micelle membranes, only acyl-CoA synthetase was inhibited by calcium ion, the apparent Ki value of calcium ion being 4.2×10<SUP>-4</SUP>M. The Km values of the enzyme for palmitate and ATP were 2.0×10<SUP>-4</SUP>m and 2.5×10<SUP>-4</SUP>m, respectively and calcium ion caused non-competitive inhibition with both palmitate and ATP. The acyl-CoA synthetase activity of lipid micellemembranes was inhibited by treatment with phospholipase A or C, but not by treatment with phospholipase D. The mechanism of inhibition of triglyceride synthesis by ACTH is discussed on the basis of these results.
- 社団法人 日本内分泌学会の論文
著者
-
OKUDA Hiromichi
Department of Medical Biochemistry, School of Medicine, Ehime University
-
SAITO YASUSHI
The 2nd Department of Internal Medicine, School of Medicine, Chiba University
-
MATSUOKA NOBUO
The 2nd Department of Internal Medicine, School of Medicine, Chiba University
-
SHIRAI KOHJI
The 2nd Department of Internal Medicine, School of Medicine, Chiba University
-
FUJII SETSURO
Division of Plasma Proteins, Institute for Protein Research, Osaka University
-
Okuda Hiromichi
Department Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
-
Kumagai Akira
The 2nd Department Of Int.med.school Of Medicine Chiba University
-
KUMAGAI AKIRA
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
-
MATSUOKA NOBUO
The 2nd Department of lntemal Medicine, School of Medicine, Chiba University
-
SHIRAI KOHJI
The 2nd Department of lntemal Medicine, School of Medicine, Chiba University
関連論文
- Antitumor and antimetastatic actions by royal jelly in Lewis lung carcinoma-bearing mice
- -121-THE RELATIONSHIP BETWEEN PLASMA RENIN ACTIVITY,PLASMA DOPAMINE β-HYDROXYLASE IN BORDERLINE AND PERSISTENT HYPERTENSION : Hypertension,Catecholamine : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Correlation of the Lipolytic Action of Synthetic Peptides with Their Structures: Importance of Acidic and Basic Amino Acid Residues in the N-Terminal Region(Biological Chemistry)
- Lysyl-Aspartic Acid Derivatives as Model Compounds of Growth Hormone to Induce Lipolysis(Biological Chemistry)
- Fatty Acid Alcohol Ester-Synthesizing Activity of Lipoprotein Lipase
- Effects of Adrenergic Blocking Agents on Lipolysis and Adenyl Cyclase Activity Induced by Vasoactive Intestinal Polypeptide (VIP)
- Studies on Reduction of Lipolysis in Adipose Tissue on Freezing and Thawing
- Ginsenosides Increase Secretion of Lipoprotein Lipase by 3T3-L1 Adipocytes
- Antitumor and antimetastatic actions by royal jelly in Lewis lung carcinoma-bearing mice
- Results of Treatment in 68 Patients with Idiopathic Aldosteronism in Japan
- Glycosylation and Secretion of Lipoprotein Lipase by 3T3-L1 Adipocytes : Effects of Brefeldin A
- Effects of a Daisaikoto Extract on the Biliary Constituents in Mice and Rats(Food & Nutrition)
- カルボキシルエステルリパーゼのアシルトランスフェラーゼ活性
- Quantitative and Qualitative Estimation of Urinary Kallikrein in a Patient with Bartters Syndrome
- Studies on Adrenaline-Induced Lipolysis in Adrenalectomized Rats
- Studies on the Mechanism of Action of ACTH on Triglyceride Synthesis in Fat Cells
- Studies on the Clinical Importance of Guanase Assayed by a Direct Colorimetric Method
- Decreased Hepatic Δ4-Reductase Activity for Aldosterone in SHR
- Participation of Amino Groups in Lipolytic Action of Growth Hormone