Quantitative and Qualitative Estimation of Urinary Kallikrein in a Patient with Bartters Syndrome
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概要
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Urinary kallikrein in a patient with Bartters syndrome was remarkably higher than normal. Indomethacin treatments increased serum potassium concentration and urinary Na/K ratio, and improved the response of blood pressure to angiotensin II infusion, while it decreased plasma renin activity, plasma aldosterone and urinary kallikrein.<BR>The purified urinary kallikrein had one component of the iso-electric point 4.3 by isoelectric focusing using Ampholine system, and its molecular weight was 4.2×10<SUP>4</SUP>, which was greater than those of three components of normal human urinary kallikreins (normal HUK). Also Km values with TAME and BAME of urinary kallikrein in our patient with Bartters syndrome did not correspond to those of normal HUK. Thus it can be said that urinary kallikrein in our patient with Bartters syndrome was qualitatively different from normal HUK. The present observation might be a reflection of renal tubular dysfunction in this patient with Bartters syndrome.
- 社団法人 日本内分泌学会の論文
著者
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Nishikawa Tetsuo
The 2nd Department Of Int.med.school Of Medicine Chiba University
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YAMADA Kenichi
The 2nd Department of Int.Med.School of Medicine,Chiba University
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WATANABE Mikio
The 2nd Department of Int.Med.School of Medicine,Chiba University
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YAMAMOTO Masahiro
The 2nd Department of Int.Med.School of Medicine,Chiba University
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KUMAGAI Akira
The 2nd Department of Int.Med.School of Medicine,Chiba University
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Mikami Keiji
The 2nd Department Of Int.med.school Of Medicine Chiba University
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Tamura Yasushi
The 2nd Department Of Int.med.school Of Medicine Chiba University
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SHIRAI KOJI
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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MATSUDA YOSHIFUMI
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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MORIYA HIROSHI
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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Watanabe Mikio
The 2nd Department Of Int.med.school Of Medicine Chiba University
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Kumagai Akira
The 2nd Department Of Int.med.school Of Medicine Chiba University
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Yamamoto Masahiro
The 2nd Department Of Int.med.school Of Medicine Chiba University
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MORIYA HIROSHI
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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KUMAGAI AKIRA
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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NISHIKAWA TETSUO
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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MIKAMI KEIJI
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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YAMADA KENICHI
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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TAMURA YASUSHI
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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WATANABE MIKIO
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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YAMAMOTO MASAHIRO
The 2nd Deartment of Internal Medicine, Chiba University School of Medicine
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