抗炎症薬に関する研究(第10報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(Y-3642)のラット肝ライソゾーム安定化作用

概要

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Effects of Y-3642 HCl on rat liver lysosome were examined in order to investigate the mode of the anti-inflammatory action. The acid phosphatase and β-glucuronidase of the lysosome fraction of rat liver were not inhibited by Y-3642 HCl. But this compound suppressed markedly the release of these two enzymes by stabilising the lysosomal membrane at low concentration at pH 7.4 or 7.0. This action of Y-3642 at pH 7.4 was more potent than that of flufenamic acid, phenylbutazone, acetylsalicylic acid and some other anti-inflammatory drugs tested. The concentration, coresponding to 20% inhibition of the acid phosphatase release, was approximately 4.7μm. This stabilizing action of lysosomal membrane by the anti-inflammatory compounds tested was parallel to that of erythrocyte membrane. Mechanism of the anti-inflammatory action of Y-3642 HCl is discussed.
社団法人日本薬学会の論文
1970-05-25