抗炎症薬に関する研究(第5報) : 2-Amino-3-ethoxycarbonyl-6-benzyl(α-^<14>C)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(^<14>C-Y-3642)のマウス生体内分布

概要

論文の詳細を見る
Radioactive compound, ^<14>C-Y-3642-(benzyl-α-^<14>C), of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c] pyridine (Y-3642) was synthesized, and the distribution of radioactivity in mouse tissues was investigated by whole body autoradio-graphy. This compound was rapidly absorbed from the site of administration, and the radioactivity was highly distributed in the liver, kidney, adrenals and brown fat after oral or intraperitoneal administrations at the dose of 100 mg/kg. But only a small amount of radioactivity was found in the blood and central nervous system. Three hours after administration of ^<14>C-Y-3642 as it was rapidly excreted the compound was scarcely detected in tissues, a large amount of it exsited in bile, urine and the gastrointestinal tract. Furthermore a part of radioactivity excreted into the gastrointestinal tract was suggested to be reabsorbed from the intestine. According to the relationship between blackening of the organs on the autoradiogram and radioactivity levels in the organs measured by a liquid scintillation counter, both data showed a good correlation under the limited radioactivity concentration.
公益社団法人日本薬学会の論文
1970-03-25