抗炎症薬に関する研究(第8報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(Y-3642)の中枢神経系, 呼吸循環系ならびに摘出臓器に対する作用

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2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c] pyridine hydrochloride (Y-3642・HCl) showed a very slight inhibitory effect on mouse locomotor activity and electric shock seizure, and did not prolong the thiopental sleep in mice. In anesthetized dogs, intravenous injection of Y-3642・HCl at 10mg/kg dose induced a marked increase of pulse rate and a slight fall in blood pressure, but there was no remarkable change in their electrocardiogram. In the isolated ileum of guinea pigs, Y-3642・HCl had a musculotropic antispasmodic action like papaverine. In anesthetized rabbits, Y-3642・HCl has no α-adrenergic blocking action or ganglion blocking action in the doses up to 10 mg/kg i.v.
公益社団法人日本薬学会の論文
1970-03-25