抗炎症薬に関する研究(第23報)Tinoridineのモルモット腹水多核白血球Lysosomeに対する膜安定化作用

概要

論文の詳細を見る
Nonsteroidal acidic anti-inflammatory drugs and steroidal anti-inflammatory agents inhibited the release of acid phosphatase from polymorphonuclear leucocyte lysosomes at pH 7.4. Tinoridine, a nonsteroidal basic anti-inflammatory drug, showed the above inhibitory activity both at pH 6.5 and 7.4,and was found to be more active than phenylbutazone or prednisolone at pH 6.5. The inhibitory activity of phenylbutazone or prednisolone at pH 6.5 was found to be remarkably lower than those at pH 7.4. Tinoridine inhibited the release of acid phosphatase from polymorphonuclear leucocytes at pH 7.4,which was induced by endotoxin, but failed to inhibit the release of aldolase from leucocytes. These findings seem to suggest that Tinoridine has a membrane stabilizing activity on leucocyte lysosomes, and this activity may be involved in the mode of anti-inflammatory action of this drug.
社団法人日本薬学会の論文
1974-06-25