向精神薬に関する研究(第4報) : ラットにおけるトリチウム標識Carpipramineの生体内運命

概要

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The metabolic fate of carpipramine labeled with tritium was investigated in rats. Radio-active carpipramine was administered p.o. or i.p. at the dose of 50 mg/kg, or p.o. at 10 mg/kg; during the following 72 hr about 3% was excreted in the urine and 80% in the feces. The same results are obtained whatever the any of administration may be. Approximately 30% of the administered dose was also excreted in the bile during the 24 hr following oral administration. Little radioactivity was found in various tissues 72 hr after oral administration. When radioactivity in the feces and bile was extracted with chloroform, both rates of extraction were clearly different, Using thin-layer chromatography, some of the radioactive metabolites were established to be glucuronides.
公益社団法人日本薬学会の論文
1970-02-25