抗炎症薬に関する研究(第14報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Hydrochlorideの毒性その1

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1) 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c] pyridine hydrochloride (Y-3642-HCl) showed a comparatively low acute toxicity in dd-mice and Wistar-King rats, irrespective of administration routes.2) When Y-3642-HCl was administered orally to rats every day in a dose of 2000 mg/kg, about half of them died of convulsion in a few days.3) The oral administration of Y-3642-HCl in a dose of 500 mg/kg/day for 4 weeks to rats inhibited an increase in body weight and induced degenerative changes in the liver. No significant change was observed in a dose lower than 125 mg/kg/day.4) When Y-3642-HCl was administered orally to rats in a dose of 125 mg/kg/day for 24 weeks, degenerative changes appeared in the liver and the kidney in a few rats. No significant change was observed in dose lower than 62.5mg/kg/day.
公益社団法人日本薬学会の論文
1970-11-25