抗炎症薬に関する研究(第16報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (Y-3642)のN-脱ベンジル化について

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^<35>S-3-Ethoxycarbonyl-^<35>S-2-amino-3-ethxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno-[2,3-c] pyridine (^<35>S-Y-3642) was metabolized in vitro to ^<32>S-2-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]-pyridine (^<35>S-debenzyl-Y-3642) by the liver homogenate of mice and rats, but was not metabolized by the brain, heart, or renal homogenate.^<35>S-Y-3642 was also slightly metabolized by the lung homogenate, while ^<35>S-debenzyl-Y-8642 was not detected. From the experiments using the subcellular fractions of rat liver, N-debenzylation reaction of ^<35>S-Y-3642 was demonstrated to occur in the microsomal fraction, and to require NADPH (NADH) and molecular oxygen.
公益社団法人日本薬学会の論文
1971-05-25