抗炎症薬に関する研究(第12報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(Y-3642)のヒト尿中代謝産物

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In the previous experiments, it was proved that the orally administered 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (Y-3642) was debenzylated in rats and mice to 2-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]-pyridine (debenzyl-Y-3642). Benzyl moiety of Y-3642 was excreted as hippuric acid into urine. The same examination was made in men. Y-3642HC1 in a dose corresponding to 100 mg of Y-3642 was given orally to men and its metabolites in the urine were examined by thin-layer chromatography. Debenzyl-Y-3642,unchanged Y-3642,hippuric acid, and several unknown metabolites were detected. Quantitative studies on the metabolites showed a tendency for hippuric acid to increase in the urine. Y-3642 was found in unchanged form at about 0.6% of the administered dose in the urine by the dilution method using ^<14>C-Y-3642. This result suggests that the metabolic fate of Y-3642 in men is quite similar to that in rats and mice.
公益社団法人日本薬学会の論文
1970-09-25