1,3-Propanediol Bis(α-p-chlorophenoxyisobutyrate)(CLY-503)のコレステロール生合成におよぼす影響

概要

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Oral administration of 1,3-propanediol bis (α-p-chlorophenoxyisobutyrate) (CLY-503) to rats in a dose of 100mg/kg/day for 7 or 12 days resulted in a decrease of serum cholesterol (25-38%) and a slight increase in liver weight, but did not influence the growth of rats. Liver cholesterol decreased 12% by the treatment for 7 days, but did not differ significantly by the treatment for 12 days (p>0.05). CLY-503 markedly inhibited incorporation of acetate-^<14>C into liver cholesterol (59-74%), but had no significant effect on that of mevalonate-^<14>C (p>0.05). No significant effect of CLY-503 was observed on the incorporation of both acetate-^<14>C and mevalonate-^<14>C into cholesterol in serum and intestinal tract wall.
公益社団法人日本薬学会の論文
1970-03-25