ピペリジン誘導体の研究(第4報)3-Oxo-1-thia-4,8-diazaspiro [4,5] decane誘導体の合成研究その2

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8-Unsubstituted-3-oxo-1-thia-4,8-diazaspiro [4,5] decane derivatives (V) were prepared from the corresponding 8-alkoxycarbonyl derivatives (IIb, c) by the Method A (HBr-AcOH), method B_1 (KOH-iso-PrOH), or method B_2 (Claisen's alkali). V were also prepared by the reaction of 4-piperidone hydrochloride (VIII) with corresponding mercapto acids and primary amines (method C). Sulfoxides (VI) of V were prepared by method A or method D_1 (oxidation of V with H_2O_2), and sulfones (VII) were prepared by method A or method D_2 (oxidation of V with KMnO_4). VI and VII were not obtained by the method B_1 or B_2. 4-Oxo-1-thia-5,9-diazaspiro [5,5] undecane (V-35) was prepared by method A or method C, and the sulfone (VII-25) of V-35 was prepared by method A.
公益社団法人日本薬学会の論文
1971-06-25