抗炎症薬に関する研究(第3報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(Y-3642)の発熱, 血管透過性および肉芽腫形成に対する効果

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2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c] pyridine hydrochloride (Y-3642 HCl) inhibited the exudate formation in formalin-induced peritonitis and granuloma pouch test in rats, and dye leakage into the peritoneal cavity in Whittle test in mice. Y-3642・HCl had no effect on normal rectal temperature of rabbits, but displayed higher antipyretic potency than aminopyrine. This compound had no inhibitory effect in granuloma formation and did not delay the process of wound healing in rats. There was no difference in anti-edematous activity of this compound between intact and adrenalectomized rats. From these results it was suggested that the anti-inflammatory activity of this compound was not mediated by the adrenocortical functions.
公益社団法人日本薬学会の論文
1970-03-25