2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)propionic Acid(Y-8004) の反復投与による身体依存性および鎮痛作用の検討

概要

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The appearance of physical dependence of 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-propionic acid (Y-8004) in mice and rats was compared with that of morphine as a control. Y-8004 and other compounds were given subcutaneously to test animals. In the mouse jumping test, no jumping was produced by levallorphan in mice treated repeatedly with Y-8004,while marked jumping was observed in mice treated repeatedly with morphine and then challenged with levallorphan. When repeated treatment with morphine in rats was discontinued or levallorphan was given instead of morphine, the decrease in body weight due to physical dependence was observed. In the case of Y-8004,any decrease was not exhibited under the same experimental conditions. No development of tolerance to analgesic and anti-inflammatory activity of Y-8004 was observed in mice and rats, respectively, by repeated administration. The analgesic activity of Y-8004 was not influenced by levallorphan and Y-8004 showed no influence on that of morphine. These findings suggest that Y-8004 may be a nonnarcotic analgesic differing from morphine or pentazocine.
公益社団法人日本薬学会の論文
1977-04-25