抗炎症薬に関する研究(第39報)2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)-propionic Acid(Y-8004)のin Vivoにおける白血球遊走および遊走白血球Lysosomeからの酵素遊離に対する作用

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In carrageenin-induced peritonitis in rats, 2-(5H[1]benzopyrano[2,3-b]pyridin-7-yl)-propionic acid (Y-8004) given orally inhibited significantly both protein exudation and leucocyte accumulation. This agent also accelerated the absorption of peritoneal fluids in prophylactic experiments, as well as the decrease of peritioneal fluids, exudative protein, and leucocyte counts in therapeutic experiments. The free activity and its ratio of lysosomal enzymes such as aryl sulfatase were found to increase markedly in the peritoneal fluids of rats with carrageenin plus zymosan-induced peritonitis. The increment may be due to the release from emigrated leucocytes during phagocytosis of zymosan. Y-8004 not only inhibited the increment but also showed the same effect on the above indexes in therapeutic experiments. These effects were also observed in the oral treatment with indomethacin, phenylbutazone, or ibuprofen. These results suggest that Y-8004 and anti-inflammatory agents used have an inhibitory activity on the release of lysosomal contents in vivo.
公益社団法人日本薬学会の論文
1976-08-25