抗炎症薬に関する研究(第30報)2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)-propionic Acid(Y-8004)のラット多形核白血球および肝Lysosomeに対する作用

概要

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Lysosome suspensions were prepared from both polymorphonuclear leucocytes and liver of rats. The incubation of the lysosomes with or without hydrogen peroxide caused the release of enzymes (acid phosphatase, aryl sulfatase), which was inhibited by 2-(5H-[1]-benzopyrano [2,3-b] pyridin-7-yl) propionic acid (Y-8004), nonsteroidal anti-inflammatory drugs such as phenylbutazone, and steroidal anti-inflammatory drugs such as prednisolone. Hydrogen peroxide not only released enzymes but also caused lipid peroxidation of the lysosome suspension. The above anti-inflammatory agents inhibited the release of enzymes more strongly than lipid peroxidation in experiments using leucocyte lysosomes. The inhibitory activity of Y-8004 and nonsteroidal anti-inflammatory drugs on the release of enzymes decreased by the addition of albumin to the incubation mixture. However, in this case, steroidal anti-inflammatory drugs retained their potent activities, and strongly inhibited the release of enzymes induced by phospholipase C. Based on these evidences, discussion was extended on the stabilizing action of Y-8004 and anti-inflammatory drugs on lysosome membranes, and on their possible mechanisms.
社団法人日本薬学会の論文
1975-09-25