心脈管系薬に関する研究(第4報) : 新Catechol誘導体のモルモット摘出気管筋標本におけるアドレナリンβ-受容体遮断作用

概要

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Anti-isoproterenol activity of 26 new derivatives of 1,2-disubstituted catechol was measured in the isolated guinea pig tracheal strip preparation. All the compounds tested antagonized the action of isoproterenol. The derivatives which had 3-tert-butylamino-2-hydroxypropyl in 1 position showed a potent activity. Among them, the compounds which had allyloxymethyl (XIII), tetrahydrofurfuryl (XVIII), or furfuryl (XIX) as a substituent at 2 position was more active than the others. 1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy) phenoxy]-2-propanol hydrochloride (XVIII), which was chemically stable among these three compounds, may be the most hopeful compound as an adrenergic β-receptor blocking agent.
社団法人日本薬学会の論文
1971-10-25