抗炎症薬に関する研究(第15報) : 2-Amino-3-ethoyxcarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Hydrochlorideの毒性その2

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2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno-[2,3-c] pyridine hydrochloride (Y-3642-HCl) was given orally to ICR-JCL mice in a dose of 1000 or 100 mg/kg/day from 7th to 12th day of pregnancy. The compound lowered the survival rate of offsprings, but did not show any influence on the development of fetuses. Y-3642-HCl displayed no marked teratogenic influence on fetuses of the mouse. Y-3642-HCl was given orally to Wistar-King rats in a dose of 700 or 70 mg/kg/day from 9th to 14th day of pregnancy. The compound, in a dose of 700 mg/kg decreased the growth rate of pregnant rats and fetuses, and delayed the development of fetuses. There was no evidence that Y-3642-HCl had any teratogenic influence on fetuses of the rat.
公益社団法人日本薬学会の論文
1970-11-25