抗炎症薬に関する研究(第25報)ラットのCarrageenin腹膜炎における抗炎症薬の白血球遊走に対する作用

概要

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Effect of anti-inflammatory agents on carrageenin-induced peritonitis in rats was studied by using leucocyte emigration, protein exudation, and absorption of peritoneal fluids as the indexes. In prophylactic experiments by oral administration, steroidal and nonsteroidal anti-inflammatory agents significantly inhibited both leucocyte emigration and protein exudation into the peritoneal cavity, and also accelerated the absorption of peritoneal fluids. In therapeutic experiments, these test compounds showed a significant effect on the absorption of both exudative protein and peritoneal fluids. On the emigrated leucocytes, nonsteroidal anti-inflammatory agents were found to decrease the number of leucocytes in the peritoneal cavity, while steroidal anti-inflammatory drugs had no such activity. These results suggest that the carrageenin-peritonitis can be regarded as a good model for experimental inflammation. Thus this method may be useful as a screening test for anti-inflammatory agents.
社団法人日本薬学会の論文
1974-10-25