<原著>若年性, 動揺性高血圧者の血行動態に対する寒冷刺激とβ-遮断剤の効果

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The change of hemodynamics by cold pressor test (CPT) was studied in 38 male students with labile hypertension. In 10 cases of those, the effect of propranolol on hemodynamics was also studied. After CPT, all subjects were divided into three groups ; CPT (+), CPT (-) and CPT (±), on the basis of, respectively, a rise more than, or less than, 20 mmHg in systolic and 15 mmHg in diastolic blood pressure, and a rise more than 20 mmHg in systolic or 15 mmHg in diastolic blood pressure. Heart rate and cardiac output were increased in the following order ; CPT (-)> CPT (±)> CPT (+), although no significant. difference was shown in both systolic and diastolic blood pressure among the three groups. On the otherhand, after administration of propranolol, the decrease in heart rate, cardiac output and systolic pressure was most prominent in the CPT (-), although only mild decrease of those parameters was shown in CPT (+) and CPT (±). These results suggest that young labile hypertension consists of two different types ; one showing hyperkinetics and normal vascular resistance, another showing normokinetics and abnormal vascular resistance.
九州大学の論文
1981-03-30