コイの脂質ハイドロパ-オキサイドの吸収〔英文〕

概要

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The metabolic pathway of lipid hydroperoxides administered orally to carp was investigated in vitro and in vivo. As the in vitro experiment, the decomposition products of 13-hydroperoxy-cis-9, trans-11-octadecadienoic acid in reaction with the carp intestinal acetone powder were analyzed after methyl esterification. Four major compounds were isolated from the reaction mixture and were identified as methyl 13-oxo-cis-9, trans-11-octadecadienate, methyl 13-hydroxy-cis-9, trans-11-octadeca-dienoate, methyl 11-hydroxy-trans-12, 13-epoxy-9-cis-octadecenoate, and methyl 9-hydroxy-trans-12, 13-epoxy-trnns-10-octadecenoate. In succession, U-14C-labeled methyl linoleate hydroperoxides were orally administered to carp, and the distribution of the radioactivity in the body was followed together with the trans-formation of hydroperoxides. After 24h, 8.3% of the dosed radioactivity was retained in the body lipids, and hydroxyoctadecadienoate and oxooctadecadienoate were identified as the major products in several organs. Whereas, hydroperoxyoctadecadienoates were almost completely absent in carp organ lipids. These results suggest that most of the administered lipid hydroperoxides are absorbed in carp after the conversion into hydroxy or oxo derivatives in the intestine.
日本水産學會の論文