ショウキョウ国内市場品の一酸化窒素産生抑制活性とLC/MSメタボローム解析

概要

論文の詳細を見る
As a part of the development of profiling analysis for Kampo medicine, ginger rhizomes (Zingiber officinale Roscoe) were collected from the Japanese market, and extracted with hot water. We evaluated their inhibitory activity on nitric oxide (NO) production by LPS/IFN-γ activated macrophages. The ginger extracts (GEs) showed weak inhibitory activity against NO production. Furthermore, we measured the total ion chromatogram (TIC) of the GEs using LC/MS to perform metabolome analysis. The result of principal component analysis (PCA) revealed that the GEs were classified into two groups. Next, orthogonal partial least squares (OPLS) were performed on the basis of NO inhibitory activity. As a result, the GEs were divided into two groups according to the strength of activity. It was shown that [6]-gingerol, the main component of ginger, contributed to the distinction of the two groups. These results suggested that [6]-gingerol might be useful as a biomarker to evaluate an anti-inflammatory effect of ginger.
2013-02-20