80 シガテラの毒化原因渦鞭毛藻Gambierdiscus toxicusの生産する抗カビ成分gambieric acids(口頭発表の部)

概要

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Marine dinoflagellates are a rich source of novel polyether compounds, some of which are chemically and pharmacologically significant, e.g., okadaic acid, maitotoxin and brevetoxins. Many of them also inhibited the growth of fungus. Therefore, we initiated screening of cultured dinoflagellates for antifungals in order to find lead compounds of pharmaceutical importance. During the screening, we found potent activity in the extracts of Gambierdiscus toxicus. The active principles named gambieric acids (GA's) were unprecedentedly potent. In terms of the minimum inhibitory dose against Aspergillus niger, 3 was 2000 time more potent than amphotericin-B. Their structures were elucidated on the basis of NMR data and found to belong to brevetoxin-type polyethers (GA-A 1, GA-B 2, GA-C 3 and GA-D 4) consisting of continuously fused 9 ether rings (7/6/6/7/9/6/6/6/6) with an additional five-membered ring in a side chain. The structures are, however, very unique in bearing a terminal carboxylic acid, and methylgultarate hemiesters in the other terminus.
天然有機化合物討論会の論文
1991-09-07